CHARLOTTE, N.C. (AP/WNCN) – Five people have been killed and at least three others seriously injured after a crash on a highway in Charlotte.

Emergency medical officials say the Friday evening crash, which involved several vehicles, happened on Interstate 485 in north Charlotte.

The wreck happened just before 8 p.m. on the inner lanes of I-485 near Oakdale Road and W.T Harris Boulevard.

The North Carolina State Highway Patrol says one vehicle was traveling on the outer lanes of I-485 when the driver, who was possibly speeding, collided with a box truck.

The box truck then lost control and went through the median and median wire barrier onto the inner loop, traveling towards oncoming traffic.

The box truck then hit two other cars traveling in the northbound lanes. All occupants of those two vehicles died.

Officials did not release the identity of the victims.

Detours were set up because the highway was closed.

Motorists in the Inner Loop must take Exit 16 (NC-16) and turn right on NC-16 South. Continue for approximately 5.5 miles to I-85. Turn left onto I-85 North. Continue on I-85 North to Exit 38 (I-77). Take Exit 38 to I-77 North. Continue on I-77 North to Exit 19 (I-485) to re-access I-485.

Motorists in the Outer Loop must take Exit 23-A (I-77 South). Continue on I-77 South to Exit 13-B (I-85 South). Take Exit 13-B onto I-85 South and continue to Exit 30(I-485) to re-access I-485.

— WJZY contributed to this report